Selank

Looking to buy Selank with confidence in purity, identity, and batch documentation? PeptideDeck lists Selank for sale in a 10mg research vial at 99%+ purity, priced to match what serious research buyers expect in 2026. This Selank price reflects direct sourcing from a vetted US supplier, third-party HPLC verification, and same-day fulfillment from a domestic warehouse. If you have been searching "Selank for sale", "buy Selank 10mg", "Selank price USA", or "where to buy Selank online", this page is the endpoint of that search. Every vial of Selank 10mg ships with a published certificate of analysis, discreet packaging, tracked delivery, and secure checkout, so researchers can focus on experimental design rather than supplier vetting.

Selank is a synthetic heptapeptide originally developed at the V.V. Zakusov Research Institute of Pharmacology of the Russian Academy of Medical Sciences. It is structurally derived from the endogenous immunopeptide tuftsin (Thr-Lys-Pro-Arg), with an added Pro-Gly-Pro C-terminal sequence that resists enzymatic degradation and extends plasma half-life. The full sequence is Thr-Lys-Pro-Arg-Pro-Gly-Pro. This modification allows Selank to cross the blood-brain barrier and maintain stability long enough to serve as a tractable research tool in behavioral neuroscience, anxiolytic screening, and neuroimmune signaling studies.

Mechanism of Action

Selank produces its documented anxiolytic-like profile in research animals through a multi-target mechanism that distinguishes it from classical benzodiazepines. Preclinical work has shown Selank upregulates expression of GABAergic pathway components and modulates the serotonergic system without directly binding the GABA-A benzodiazepine site. In rodent models, administration of Selank changes expression of genes involved in serotonin metabolism, increases tryptophan hydroxylase activity, and alters the balance of serotonin and its metabolite 5-HIAA. This indirect serotonergic modulation appears to underlie the anxiolytic-like effects observed in elevated plus-maze and open-field paradigms.

Selank also influences the enkephalinergic system. It inhibits enkephalin-degrading enzymes, prolonging endogenous enkephalin activity and amplifying signaling at opioid receptors without itself acting as a direct opioid agonist. This enzyme inhibition appears to contribute to the observed stress-buffering profile in animal studies.

A third pillar of Selank pharmacology is immunomodulation. Because tuftsin is a native immunopeptide, Selank retains activity on cytokine networks. Published research shows Selank administration alters the expression of interferons and interleukins, modulates Th1/Th2 cytokine balance, and influences peripheral immune cell signaling. This neuroimmune crosstalk is one of the more active areas of current Selank research, since the HPA axis, inflammation, and anxiety behavior are tightly linked in preclinical models.

Finally, Selank appears to affect BDNF expression and synaptic plasticity markers in hippocampal and cortical tissue, which may explain why research animals show improvements in learning and memory paradigms alongside anxiolytic-like effects. The combination of GABAergic upregulation, serotonergic modulation, enkephalin potentiation, and neuroimmune effects gives Selank a uniquely broad research profile.

Chemical Profile

Selank is a linear heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro and a molecular formula of C33H57N11O9. The molecular weight is approximately 751.87 g/mol. CAS registry 129954-34-3. The compound is supplied as a white lyophilized powder, sealed under vacuum in amber or clear borosilicate vial glass, and is soluble in bacteriostatic water and sterile saline. Selank is stable in its lyophilized form at minus 20 degrees Celsius for extended periods, and the published literature supports stability at room temperature for short shipping windows without meaningful loss of peptide integrity. Reconstituted solutions should be kept refrigerated. The tuftsin-derived N-terminus is responsible for the immunomodulatory signature, while the Pro-Gly-Pro C-terminal cap confers the enzymatic stability that separates Selank from endogenous tuftsin.

Research Applications

Selank has been used across a broad preclinical research footprint. Anxiolytic screening remains its most cited research application: rodent elevated plus-maze, open-field, and light-dark box paradigms all show Selank administration producing effects comparable in direction to benzodiazepine reference compounds, with a notably cleaner profile regarding sedation, motor impairment, and withdrawal markers. Researchers studying anxiety circuits find Selank useful because it allows dissociation of GABAergic tone from direct receptor agonism.

A second active area is stress physiology. Selank has been investigated in chronic restraint, social defeat, and forced-swim models, where it appears to buffer HPA axis output and normalize corticosterone responses. Gene expression studies in the prefrontal cortex and hippocampus show Selank alters transcripts related to stress-responsive neuropeptides and neurotrophic factors.

Selank also sees use in cognition research. Passive avoidance, Morris water maze, and novel object recognition studies report procognitive signals, particularly in aged or stress-loaded cohorts. The proposed mechanism involves BDNF upregulation and enhanced cholinergic tone, though the full signaling picture is still being mapped.

Neuroimmune research is another expanding domain. Because Selank is derived from tuftsin, it retains measurable effects on macrophage activation, cytokine release, and interferon expression. Studies examining the gut-brain-immune axis use Selank as a probe for linking peripheral immune status to CNS behavioral outcomes.

Selank is strictly a research tool in this jurisdiction. It is not approved by the FDA and is not intended for human or veterinary use, diagnosis, or treatment. All descriptions on this listing refer to published preclinical and exploratory research contexts only.

Reconstitution & Dosing Reference

For laboratory reconstitution, Selank is typically dissolved in bacteriostatic water containing 0.9% benzyl alcohol. A common working reconstitution is 2 mL of bacteriostatic water added to a 10mg vial, yielding a concentration of 5 mg/mL. Using an insulin syringe calibrated in 100 IU units, each 10 IU increment on the syringe corresponds to 0.1 mL of solution, which is 0.5 mg of Selank at the 5 mg/mL concentration. Researchers selecting a 1 mg/mL stock instead can reconstitute with 10 mL of bacteriostatic water, in which case each 10 IU mark equals 0.1 mg. Gently swirl the vial after adding diluent. Do not shake or invert vigorously, as peptide chains can fragment under mechanical stress. Allow the solution to clarify before withdrawing. These values are provided strictly as a research reconstitution reference for in-vitro laboratory work and do not constitute a human-use protocol.

Storage & Handling

Store lyophilized Selank at minus 20 degrees Celsius, protected from light and moisture, for long-term stability. The unopened vial is stable for 24 months or longer under these conditions. Short transit periods at ambient temperature do not meaningfully degrade the peptide, which is one reason Selank is well suited to distributed laboratory networks. Once reconstituted with bacteriostatic water, Selank solution should be refrigerated at 2 to 8 degrees Celsius and used within 30 days. Avoid repeated freeze-thaw cycles on reconstituted material, since cycling accelerates aggregation and loss of peptide integrity. Keep the vial upright, protect the rubber stopper from contamination, and swab with 70% isopropyl alcohol before each withdrawal.

Where to Buy Selank

PeptideDeck connects research buyers to a vetted US supplier offering Selank 10mg at a fair 2026 price with a published certificate of analysis. When researchers ask us where to buy Selank online without worrying about purity, identity, or whether the vial that arrives matches the label, this is the listing we direct them to. The supplier ships from a US warehouse, which means domestic researchers avoid customs delays and international seizure risk. Click Add to Cart to confirm stock and complete checkout through our secure partner. If you are comparing the Selank price across sources, remember to compare at matched purity (99%+), matched dose (10mg), and matched documentation (per-lot COA), because "Selank for sale" listings without those signals are not equivalent products. Bulk research purchases and multi-vial Selank orders can qualify for volume discounts when processed through the partner checkout.

Quality Assurance & COA

Every vial of Selank 10mg sold through this listing is backed by batch-level quality documentation. Purity is verified by reverse-phase HPLC at 99% or higher, with identity confirmed by mass spectrometry matching the expected Thr-Lys-Pro-Arg-Pro-Gly-Pro molecular weight. The supplier publishes certificates of analysis per lot, documenting peptide content, residual solvent, and microbial testing. Independent third-party laboratory verification is performed on representative lots to confirm the in-house HPLC data. The supplier operates under cGMP-aligned manufacturing practices in a controlled-environment facility. Researchers who want to review the COA prior to purchase can request the specific lot certificate through the partner vendor. This quality trail is what separates credible Selank suppliers from generic commodity listings and is why we recommend this source to anyone searching for Selank for sale with documentation they can cite in a lab notebook.