Mounjaro Dosage Chart & Titration Schedule.
Mounjaro (tirzepatide) is a dual GIP/GLP-1 receptor agonist approved for Type 2 diabetes management. It follows the same gradual 6-step titration as Zepbound, escalating from 2.5 mg to a 15 mg maximum dose over 20 weeks to minimize gastrointestinal side effects.
Half-Life
~5 days
Injection
Subcutaneous
Frequency
Once weekly
Storage
2 – 8 °C
Titration Schedule
Standard dose escalation from 2.5 mg to the 15 mg maintenance dose over 20 weeks. Each step lasts 4 weeks. Not all patients need to reach 15 mg — 5 mg or 10 mg may be used as maintenance doses if well tolerated.
Using compounded tirzepatide? Use the calculator below to find your exact draw volume.
2.5 mg
per injection · Weeks 1 – 4
Frequency
1× / week
Monthly Total
10 mg
Purpose
GI tolerance / starter dose
2.5 mg/wk
5 mg
per injection · Weeks 5 – 8
Frequency
1× / week
Monthly Total
20 mg
Purpose
First therapeutic dose
5 mg/wk
7.5 mg
per injection · Weeks 9 – 12
Frequency
1× / week
Monthly Total
30 mg
Purpose
Continued escalation
7.5 mg/wk
10 mg
per injection · Weeks 13 – 16
Frequency
1× / week
Monthly Total
40 mg
Purpose
Therapeutic range
10 mg/wk
12.5 mg
per injection · Weeks 17 – 20
Frequency
1× / week
Monthly Total
50 mg
Purpose
High-dose escalation
12.5 mg/wk
15 mg
per injection · Week 21 onward
Frequency
1× / week
Monthly Total
60 mg
Purpose
Maximum maintenance dose
15 mg/wk
Pick Your Injection Day
Mounjaro is injected once per week on the same day. Choose whichever day fits your routine best and stay consistent.
| Day | Mon | Tue | Wed | Thu | Fri | Sat | Sun |
|---|---|---|---|---|---|---|---|
| Option A | |||||||
| Option B | |||||||
| Option C |
Compounded Tirzepatide Reconstitution Calculator
For compounded tirzepatide vials — enter your vial size, how much bacteriostatic water you added, and your target dose to find the exact draw volume.
Double-click a preset to edit it
Double-click a preset to edit it
Double-click a preset to edit it
Standard insulin syringe
Concentration
2.50 mg/mL
Draw volume
1.000 mL
= 2.5 mg ÷ 2.50 mg/mL
Units to draw (1 mL syringe)
100 units
1 mL Syringe
100 IUTips & Notes
Timing & Consistency
Inject on the same day each week at any time, with or without food. If you miss a dose and fewer than 4 days have passed, inject as soon as possible. If 4 or more days have passed, skip it and resume the following week on your regular schedule.
Injection Sites
Inject subcutaneously into the abdomen (at least 2 inches from the navel), front of the thigh, or upper arm. Rotate injection sites each week to prevent lipodystrophy and improve absorption.
Managing Side Effects
Nausea, vomiting, diarrhea, and constipation are most common during the first weeks of each new dose and during escalation. If GI effects are severe or persistent, stay at the current dose for an additional 4 weeks before escalating. Do not skip titration steps.
Storage
Store unused pens or vials at 2 – 8 °C in the refrigerator. Mounjaro pens can be kept at room temperature (up to 30 °C / 86 °F) for up to 21 days. Never freeze tirzepatide — freezing degrades the molecule. Compounded vials should be used within 28 days of reconstitution.
Disclaimer: Mounjaro (tirzepatide) is an FDA-approved prescription medication for Type 2 diabetes — it must be prescribed and supervised by a licensed healthcare provider. Compounded tirzepatide is not FDA-approved. Always consult a qualified physician before starting, adjusting, or stopping any treatment.