Semaglutide Dosage Chart & Schedule Guide.
Semaglutide is a GLP-1 receptor agonist used for weight management and blood sugar control. It follows a gradual titration schedule over 16+ weeks to minimize side effects and optimize results.
Half-Life
~7 days
Injection
Subcutaneous
Frequency
Once weekly
Storage
2 – 8 °C
Titration Schedule
Standard dose escalation from 0.25 mg to the 2.4 mg maintenance dose over 16 weeks. Each step lasts 4 weeks.
Compounded semaglutide vials vary in concentration. Use the calculator below to find your exact draw volume.
0.25 mg
per injection \u00b7 Weeks 1 – 4
Frequency
1× / week
Monthly Total
1 mg
Purpose
Initial tolerance
0.25 mg/wk
0.5 mg
per injection \u00b7 Weeks 5 – 8
Frequency
1× / week
Monthly Total
2 mg
Purpose
Dose escalation
0.5 mg/wk
1.0 mg
per injection \u00b7 Weeks 9 – 12
Frequency
1× / week
Monthly Total
4 mg
Purpose
Therapeutic range
1.0 mg/wk
1.7 mg
per injection \u00b7 Weeks 13 – 16
Frequency
1× / week
Monthly Total
6.8 mg
Purpose
Continued escalation
1.7 mg/wk
2.4 mg
per injection \u00b7 Week 17 onward
Frequency
1× / week
Monthly Total
9.6 mg
Purpose
Maintenance dose
2.4 mg/wk
Pick Your Injection Day
Semaglutide is injected once per week on the same day. Choose whichever day fits your routine best.
| Day | Mon | Tue | Wed | Thu | Fri | Sat | Sun |
|---|---|---|---|---|---|---|---|
| Option A | |||||||
| Option B | |||||||
| Option C |
Reconstitution Calculator
For compounded semaglutide vials: enter your vial size, how much water you added, and the dose you want.
Standard insulin syringe
Concentration
2.50 mg/mL
Draw volume
0.100 mL
= 0.25 mg ÷ 2.50 mg/mL
Units to draw (1 mL syringe)
10 units
1 mL Syringe
10 IUTips & Notes
Timing & Consistency
Inject on the same day each week, at any time of day, with or without food. If you miss a dose and it has been less than 5 days, take it as soon as possible. Otherwise, skip and resume the following week.
Injection Sites
Inject subcutaneously into the abdomen, front of thigh, or upper arm. Rotate injection sites each week to prevent lipodystrophy and reduce injection-site reactions.
Side Effects & Titration
Nausea is the most common side effect, especially during dose increases. If side effects are severe, stay at the current dose for an extra 4 weeks before escalating. Do not skip titration steps.
Storage
Store unopened pens or vials in the refrigerator at 2 – 8 °C. Once in use, compounded vials should be refrigerated and used within 28 days. Never freeze semaglutide.
Disclaimer: This content is for informational purposes only. Semaglutide is a prescription medication. Always consult a qualified healthcare professional before starting or adjusting any treatment. PeptideDeck is not responsible for individual use.