Sermorelin Dosage Chart.
Sermorelin is a growth hormone-releasing hormone (GHRH) analog that stimulates your pituitary gland to produce more natural GH. It's used for anti-aging, recovery, sleep quality, and body composition.
200 – 300 mcg under the skin before bed, 5 nights per week, for 3 – 6 months. New to sermorelin? 100 mcg for the first two weeks. Inject at least 1 hour after eating.
Dosage Protocols
Units assume a 9 mg vial mixed with 9 mL of bacteriostatic water (1,000 mcg/mL). Different setup? Use the calculator. The tiers track experience, not a ladder to climb.
Start at 100 mcg for two weeks to check tolerance, then move up to 200 mcg.
Why this dose+
The first two weeks are a tolerance check, not a therapeutic dose: you are finding out how you sleep on it and how the injection site behaves before committing to a full vial. Five nights on and two off from the start keeps the routine identical once you move up.
Where most people settle once injections are routine and a first cycle is behind them.
Why this dose+
This is the range that gets a meaningful nightly GH pulse without pushing into the flat part of the curve. Two rest nights a week are there to keep the pituitary responsive, which is why the weekly total matters more than any single night.
For people several cycles in, usually supervised by a clinician or stacked with another GH peptide.
Why this dose+
Past this range the pituitary sets the ceiling, not the syringe, so extra micrograms mostly go unused. That is why the usual next step is pairing sermorelin with a peptide that works through a different receptor rather than pushing the dose higher.
- Inject 30 – 60 minutes before bed so the dose lands on your natural GH pulse.
- Empty stomach: at least 1 hour after eating, and nothing for 30 minutes after.
- 5 nights on, 2 off is the standard pattern for preventing desensitization.
- One injection is one pulse, so a missed night is skipped, not doubled up.
- Your pituitary can only release so much GH per pulse, whatever the dose.
- Doses above 500 mcg mostly hit that ceiling rather than adding output.
- Check your timing and product quality before reaching for a higher number.
- A different receptor (an ipamorelin stack) is the usual next step, not more mcg.
Weekly Schedule
Pick one row and keep it identical week to week: 5 nights on, 2 off, injected 30 – 60 minutes before bed.
Missed a night? Skip it and carry on the next evening. Sermorelin works pulse by pulse, so a bigger dose cannot make up a missed one.
Reconstitution Calculator
Enter your vial size, how much water you added, and the dose you want. We'll tell you exactly how much to draw.
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Standard insulin syringe
Concentration
1.00 mg/mL
1 unit = 10 mcg
Draw volume
0.300 mL
= 300 mcg ÷ 1000 mcg/mL
Units to draw (1 mL syringe)
30.0 units
1 mL Syringe
30.0 IUFrom Vial to Injection in 6 Steps
Alcohol swab on the sermorelin vial and the bacteriostatic water vial. Let them air-dry.
Draw your bacteriostatic water and inject it down the inside wall of the vial, never straight onto the powder.
Gently roll the vial until the powder dissolves fully (1 – 2 minutes). Shaking damages the peptide.
Use a fresh U-100 insulin syringe (29 – 31G). Pull to the unit mark from the calculator. Flick out air bubbles.
Pinch skin 2+ inches from your navel, insert at 45 – 90°, push slowly, hold 5 seconds. Rotate sites each night.
Store the mixed vial at 2 – 8 °C and use within 4 weeks. Never freeze. Dispose of needles in a sharps container.
What to Expect
Sermorelin raises your own GH gradually, so changes compound over months, not days. If nothing has changed by week 8, review your dose, timing, and product quality.
More vivid dreams and waking more rested within the first 2 weeks, the earliest and most reliable sign it's working.
Better daytime energy, faster recovery between workouts, less lingering soreness.
Improved skin elasticity and tone, stronger nails and hair, steadier mood.
Gradual fat loss and lean muscle gain: the slowest change, and the one that depends most on training and diet.
Feeling Something? Check Here
Skip sermorelin entirely (until a doctor says otherwise) if you: have or had cancer · are pregnant or breastfeeding · have diabetes or insulin resistance · have untreated thyroid problems · take corticosteroids or thyroid medication.
FAQ
What if I miss a dose?+
Skip it and inject as normal the next evening. Never double up; sermorelin triggers one GH pulse per injection, so a larger dose can’t compensate for a missed night.
Can I take it in the morning instead?+
Bedtime is strongly preferred because it stacks with your natural nighttime GH pulse. If evenings are impossible, morning on an empty stomach (30+ min before food) is second-best. Just be consistent.
Why do I need an empty stomach?+
Food, especially carbs and fat, raises insulin and blood sugar, which blunt GH release. Wait at least 1 hour after your last meal, and don’t eat for 30 minutes after injecting.
How long does a vial last?+
A 9 mg vial at 300 mcg per night, 5 nights a week, gives 30 doses, about 6 weeks. Use the calculator above with your own numbers. Once mixed, use the vial within 4 weeks.
Does the injection hurt?+
Insulin needles (29 – 31G) are very thin; most people feel a small pinch at most. Injecting slowly and rotating sites keeps irritation down.
Can I stack it with CJC-1295 or ipamorelin?+
Sermorelin and ipamorelin work through different receptors and are commonly combined for a stronger GH pulse. Don’t stack it with CJC-1295; they’re both GHRH analogs, so it’s redundant. Start each compound solo first so you know what’s causing what.
Do results stay after I stop?+
Sleep and energy benefits fade over a few weeks as GH returns to baseline. Body-composition changes stick around as long as your training and diet hold. Many people cycle: 3 – 6 months on, 1 – 2 months off.
Sermorelin vs. HGH: what’s the difference?+
HGH replaces growth hormone directly; sermorelin asks your pituitary to make more of its own. Sermorelin is gentler, preserves the natural pulse and feedback loops, and can’t push GH above what your body allows, which is also why its effects are milder.
Disclaimer: This content is for informational and research purposes only and is not medical advice. Sermorelin is a prescription compound in many countries. Always consult a qualified healthcare professional before starting any peptide protocol. PeptideDeck is not responsible for individual use.