MK-677 Dosage Chart & Schedule Guide.
MK-677 (Ibutamoren) is a GH secretagogue that stimulates sustained GH and IGF-1 production by mimicking ghrelin. The injectable form delivers the same daily doses subcutaneously, bypassing first-pass metabolism and producing a rapid Tmax while maintaining the characteristic ~24-hour IGF-1 elevation.
Half-Life
~24 hours
Injection
Subcutaneous
Frequency
Once daily
Storage
2 – 8 °C
Dosage Protocols
Dose per injection, frequency, and total weekly amount across protocol levels.
Syringe units assume a 25 mg vial mixed with 2 mL bacteriostatic water (12.5 mg/mL). Use the calculator below for your exact setup.
10 mg
per injection · ~16 units
Frequency
Daily
Weekly Total
70 mg
Cycle Length
2 – 4 weeks
10 mg/day
20 mg
per injection · ~32 units
Frequency
Daily
Weekly Total
140 mg
Cycle Length
12 – 16 weeks
20 mg/day
25 mg
per injection · ~40 units
Frequency
Daily
Weekly Total
175 mg
Cycle Length
16 – 20 weeks
25 mg/day
Weekly Schedule
Inject once daily at the same time each day. Bedtime is preferred — MK-677 amplifies the natural nocturnal GH pulse and hunger side effects are less disruptive during sleep.
| Protocol | Mon | Tue | Wed | Thu | Fri | Sat | Sun |
|---|---|---|---|---|---|---|---|
| Beginner | |||||||
| Standard | |||||||
| Advanced |
MK-677 Reconstitution Calculator
For lyophilized MK-677 vials: enter your vial size, how much bacteriostatic water you added, and your target dose.
Note: many injectable MK-677 products ship as pre-dissolved solutions (e.g. 25 mg/mL ready-to-inject) — no reconstitution needed for those. This calculator is for dry powder vials only.
Standard insulin syringe
Concentration
12.50 mg/mL
Draw volume
0.800 mL
= 10 mg ÷ 12.50 mg/mL
Units to draw (1 mL syringe)
80 units
1 mL Syringe
80 IUTips & Notes
Injection Sites & Technique
Inject subcutaneously into the abdomen, front of thigh, or outer upper arm. Pinch the skin, insert the needle at 45°, and inject slowly. Rotate sites daily to prevent lipodystrophy and reduce local irritation.
Managing Hunger
MK-677 mimics ghrelin — increased appetite is expected, especially in the first 2–3 weeks. Plan higher-protein meals and avoid late-night calorie-dense snacking. Hunger typically subsides as the body adapts to elevated ghrelin signaling.
Cycling & IGF-1 Monitoring
Standard cycles run 12–16 weeks followed by an equal-length break. During extended cycles, monitor IGF-1 levels — sustained supraphysiological IGF-1 is the primary long-term consideration. Blood glucose should also be tracked, particularly in pre-diabetic individuals.
Storage
Store unreconstituted vials at 2–8 °C (or frozen at −20 °C for long-term). After reconstitution with bacteriostatic water, refrigerate and use within 28 days. Pre-dissolved liquid solutions should be refrigerated immediately and used within the vendor-specified window.
Disclaimer: This content is for informational purposes only. MK-677 is a research compound with no approved injectable pharmaceutical formulation. All injectable protocols are community-derived. Always consult a qualified healthcare professional before starting any new compound. PeptideDeck is not responsible for individual use.