-15%KPV Capsules
250mcg per capsule · 60 capsules · Tripeptide (alpha-MSH) · Limitless Life Nootropics
Price with PeptideDeck coupon applied at checkout
PeptideDeck
≥98% Purity
Third-party verified
60 Capsules
250mcg each
GMP Compliant
USA manufactured
Tripeptide
From alpha-MSH
About KPV
KPV is a tripeptide (Lys-Pro-Val) derived from the C-terminal end of alpha-melanocyte-stimulating hormone (alpha-MSH). It retains the powerful anti-inflammatory properties of the parent hormone while being significantly smaller and more stable. KPV works primarily through inhibition of the NF-κB inflammatory pathway, reducing the production of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β. It is widely used for gut inflammation, skin conditions, and broad immune modulation.
Product Specifications
Recommended Dosage
Common dosage protocols based on community experience.
Key Benefits
Gut Inflammation & IBD Support
KPV delivers powerful anti-inflammatory effects for the digestive tract. It reduces colonic inflammation by inhibiting NF-κB activation in intestinal epithelial cells and immune cells, helping manage conditions like colitis and Crohn's disease.
Skin Conditions & Dermatitis Relief
KPV reduces skin inflammation and accelerates wound healing. It modulates inflammatory responses in keratinocytes and is effective for managing contact dermatitis, psoriasis, and other inflammatory skin conditions.
Immune Modulation
KPV exerts broad immunomodulatory effects by suppressing pro-inflammatory cytokines including TNF-α, IL-6, and IL-1β. It helps regulate the immune response without causing immunosuppression, maintaining the body's ability to fight pathogens.
Antimicrobial Properties
KPV possesses direct antimicrobial activity against certain bacteria, including Staphylococcus aureus and Candida albicans. This dual anti-inflammatory and antimicrobial action makes it uniquely valuable for addressing infection-related inflammation.
Mucosal Healing
KPV promotes mucosal tissue repair in the gastrointestinal tract by reducing inflammatory signaling and supporting epithelial barrier integrity. It helps restore tight junction proteins and accelerates recovery of damaged mucosal surfaces.
How KPV Works
KPV exerts its anti-inflammatory effects primarily through inhibition of the NF-κB signaling pathway, one of the master regulators of inflammation in the body. By preventing NF-κB from translocating to the nucleus, KPV effectively reduces the transcription of pro-inflammatory genes, leading to decreased production of cytokines such as TNF-α, IL-6, and IL-1β.
Unlike the full-length alpha-MSH hormone from which it is derived, KPV does not significantly activate melanocortin receptors responsible for skin pigmentation. Instead, it enters cells and interacts directly with intracellular inflammatory signaling cascades, providing targeted anti-inflammatory action without melanogenic side effects.
KPV also modulates immune cell behavior, reducing the activation of macrophages and dendritic cells while preserving their ability to respond to genuine threats. In the gut, KPV crosses the intestinal epithelium and reduces mucosal inflammation, supporting epithelial barrier function and promoting tissue repair.
Frequently Asked Questions
What is KPV?
KPV is a tripeptide consisting of the amino acids lysine-proline-valine (Lys-Pro-Val). It is derived from the C-terminal end of alpha-melanocyte-stimulating hormone (alpha-MSH) and retains the potent anti-inflammatory properties of the parent hormone without causing skin-darkening effects.
How does oral KPV compare to injectable KPV?
Oral KPV capsules are absorbed through the gastrointestinal tract, making them especially effective for gut-related inflammation. Injectable KPV provides higher systemic bioavailability. Oral capsules are the most convenient and accessible form for everyday use.
Can I combine KPV with BPC-157?
Yes, KPV and BPC-157 are commonly stacked together for synergistic gut-healing benefits. KPV targets inflammation via NF-κB inhibition while BPC-157 promotes angiogenesis and tissue repair, addressing complementary mechanisms for GI tract recovery.
What are the side effects of KPV?
KPV is generally very well-tolerated. As a naturally derived fragment of alpha-MSH, it has a favorable safety profile. Unlike full-length alpha-MSH, KPV does not cause significant tanning effects. Mild GI effects have been occasionally reported at higher doses.
How should I store KPV capsules?
Store KPV capsules at room temperature in a cool, dry place away from direct sunlight and moisture. Refrigeration is not required but can help extend shelf life. Keep the container tightly sealed between uses.